You may have heard that disk only backups are fine. At Corporate Computer, Inc, our policy is to always have a tape archive. Disk backups tend to provide a false sense of security. Consider having a computer with a lot of hard disk space and then setup a disk to disk backup using the ntbackup program that is included with Windows. Then backup your disk backup files to tape. There are many easy to use tape backup software, one that many of our clients find easy to use is BACKUP ASSIST . And don't forget to check your backup logs. Be proactive dangit!
Consider how bad companies have been distroyed by lack of backups. The folks at Journalspace.com just this past month lost everything when the hard disk mirror lost the data, then replicated the corruption to the mirror disks.